Interdisciplinary Centrum for Radiosurgery

Gamma Knife

Prof. Dr. med. Bodo Lippitz

Oral Presentations 2012-2014


1. Tagung der Sektion Stereotaxie und Radiochirurgie der Deutschen Gesellschaft für Neurochirurgie, München, LMU, Klinikum der Universität München, February 3rd-4th, 2012

Presentation: Bestimmt die Anzahl der Hirnmetastasen die Prognose?

Presentation: 10-Jahres-Verlaufsuntersuchung in der Gamma Knife Behandlung intracerebraler Meningiome

2. XXth Anniversary of the Marseille Radiosurgery Program, Marseille, February 16th, 2012

Presentation: Gamma Knife Radiosurgery‘Perfexion’: A Paradigm Shift in the Treatment of Brain Metastases


Fondacion Gruppo IMO, Madrid March, 12th-14th, 2012

Presentation: Radiosurgery in Current Global Health Economic Trends

Presentation: Gamma Knife Radiosurgery of Solitary Brain Metastases

4. Annual Meeting: Svenska Hjärntumörsföreningen 2012, Stockholm, March 29th, 2012

Presentation:  Minimal Invasiv Behandling av Hjärntumörer

5. I Jornada de Metastasis Cerebrales, Salon de actos del hospital Clinico San Carlos, Madrid, Spain, April 26th 2012,

Presentation: Radiosurgery in Current Global Health Economic Trends

6. Bupa Seminar: Best Management Series: New Developments in the treatment of Metastatic Disease, Royal College of Surgeons, London May 25th, 2012

Presentation: Treatment of brain metastases using Gamma Knife radiosurgery

Presentation: Gamma Knife radiosurgery for recurrent metastases after failed fractionated whole Brain Radiotherapy

7. Second Annual Brain Metastases Research and Emerging Therapy Conference, Marseille, France September 5th, 2012

Presentation: MR changes and their Interpretation following radiosurgical treatment of brain metastases

8. From The Laboratory to the Clinic: Towards New Treatment of Inflammatory Diseases: Oxford Trinity College, September 10-13, 2012

Presentation: Circumstantial evidence for a uniform cytokine reaction pattern in cancer patients

9. Opening Ceremony Gamma Knife Center Curitiba, Brazil October 2nd, 2012

Presentation: Current Indications for Gamma Knife Radiosurgery: an overview

10. 13th Congress of the Spanish Radiosurgical Society, October 17-19th 2012, San Sebastian, Spain

Presentation: Radiosurgery in Current Global Health Economic Trends in Europe

11. LV Annual Chilean Congress of Neurosurgery, October 24-27th, 2012, Pürto Varas, Chile.

Presentation: Gamma Knife treatment of Trigeminal Neuralgia

Presentation: Alternatives in the treatment of pituitary adenoma

12. SK kurs endokrinologi (post-graduate course endocrinology) Karolinska University Hospital Huddinge, Stockholm 13th November, 2012

Presentation: Radiokirurgisk behandling av patienter med hypofysadenom

13. Symposium „Gamma Knife Center Tilburg: 10 years and 5000 patients later, controversies in Radiosurgery“ Amsterdam, November 23rd, 2012.

Moderator of Point-counterpoint discussion: Minesh Mehta vs. Jonathan Kniseley

Presentation: Treatment of Multiple Brain Metastases

14. Annual European Gamma Knife Society Meeting 24th November, 2012 Amsterdam, Netherlands

Presentation: Developments 2010-2012: State-of-the-art in the Treatment of Brain Metastases



15. Annual Meeting of the Swedish Pituitary Group (Möte i Svenska Hypofysgruppen), Sky City, Arlanda Stockholm February 8th, 2013

Presentation: Gamma Knife Radiosurgery in the Treatment of Pituitary Adenoma

16. Symposium 20 Anni della Gamma Knife a Verona, March 1st, 2013, Azienda Ospedaliera Universitaria Integrata, Verona, Italy

Presentation: Aspetti e confronti internazionali del sistema di rimborso

17. Symposium Experiences and Perspectives in Gamma Knife Radiosurgery, Hôpital Universitaire Pitié Salpetrière, April 12th, 2013-05-18

Presentation: Radiosurgery for Benign Tumors

18. 4th Annual Meeting British Radiosurgery Society in Sheffield, 21th May 2013, Sheffield Hallam University, United Kingdom

Presentation: 2010-2013 Recent Developments in Gamma Knife treatments for Brain Metastases

19.  Radiumhemmet Karolinska Hospital Stockholm, Sweden June 14th, 2013

Presentation: Stereotaktisk radiokirurgisk behandling av hjärnmetastaser I Gamma Knife

20. ISRS 2013: 11th International Stereotactic Radiosurgery Society Congress, June 16-20th, 2013, Toronto, Canada

Presentation: Principles of Radiosurgery

21.  Röntgenvecka Uppsala September 2-6th, 2013, Uppsala Sweden

Presentation: Gamma Knife Radiokirurgi

22. Elekta User Group Meeting September 12-13th, 2013, Rhodes, Greece

Chair: Abstract Presentations

23.  Current Standards and Controversies in the Management of Cerebral Metastatic Disease, 4th October, 2013, Great Hall St Bartholomew’s Hospital London, UK

Presentation: Adverse radiation effects based on 130 patients with larger Brain metastases with a survival of more than 9  months



24. Meeting Bröstcancerförening Stockholm January 24th, 2014

Presentation: Stereotactic Radiosurgery in the Treatment of Brain Metastases

25. SK kurs (specialistkompetenskurs) Karolinska Huddinge: Neurokirurgisk Behandling av cerebrala metastaser: January 31th, 2014

26. 17th International Meeting of the Leksell Gamma Knife Society, New York May 11-15th, 2014

Moderator: Session Cost-Effectiveness and Reimbursement from a Global Perspective

Moderator: Flash Oral Poster session

Presentation: 10-Year Follow-up after Gamma Knife radiosurgery of Meningioma

Presentation: Algorithm to Avoid Adverse Radiation Effects after Gamma Knife Radiosurgery of Brain Metastases

Presentation: 10-Year Follow-up after Gamma Knife radiosurgery of Pilocytic Astrocytoma

27.  5. DEGRO (Deutsche Gesellschaft für Radio-Onkologie) Workshop für KAI, Freiburg, Germany, May14th, 2014

Presentation: Wettlauf der Giganten: Gesundheitsökonomie in Grossbritannien, Schweden und Deutschland

28. European Association of Neurosurgery Pragü October 12-17th, 2014, Pragü, Czech Republic

Presentation: Radiosurgery in the Treatment of Brain Metastases: Why the Paradigms Are Changing

Printed Publications 2004-2014

1. Lippitz BE , Kräpelien T, Hautanen K, Ritzling M, Rähn T, Ulfarsson E, Böthius J : Gamma Knife Radiosurgery for Patients with Multiple Cerebral Metastases; Acta Neurochirurgica (2004) (Suppl) 91: 79-87

2. Lippitz B. [Gamma knife surgery improves the treatment of intracranial tumors][Article in Swedish] Läkartidningen 2004 Sep 30;101(40):3078-80.

3. Bodo E. Lippitz: Gamma Knife Radiosurgery in the Minimal Invasive Treatment of Brain Metastases: The State-of-the-Art Rivista Medica, 2005, 11(1-2) 31-37

4. Paddick I., Lippitz BE. A simple dose gradient measurement tool to complement the conformity index. J Neurosurg (Suppl) 105: 194-201, 2006

5. Bodo E. Lippitz :Treatment of Brain Metastases using Gamma Knife Radiosurgery: The Gold Standard; European Neurological Review, Vol. 3 Issü 1, 2008

6. Mikäl Söderman, Bengt Karlsson, Bodo Lippitz., Tommy Andersson: Stereotactic Radiosurgery for Arterio-venous Fistula in In: Lunsford LD, Sheehan J, eds. Intracranial stereotactic radiosurgery. New York: Thieme Medical Publishers; 2010: 41-47

7. B.Lippitz: Health Economy in Gamma Knife Radiosurgery, White Paper 2013

8. B.Lippitz: Treatment of cavernoma: an evidence-based dilemma? Acta Neurochir Suppl. 2013;116:99-101.

9. Lippitz BE. Cytokine patterns in patients with cancer: a systematic review. Lancet Oncol. 2013 May;14(6):e218-28.

10. Lippitz BE, Lindquist C, Paddick I, Peterson D, O‘Neill K, Beaney R. Stereotactic radiosurgery in the treatment of brain metastases: the current evidence. Cancer Treat Rev. 2014 Feb;40(1):48-59.

11. Dodoo E, Huffmann B, Peredo I, Grinaker H, Sinclair G, Machinis T, Enger PO, Pedersen PH, Skeie B, Ohlsson M, Orriego A, Kräpelien T, Barsoum P, Benmakhlouf H, Herrman L, Svensson M, Lippitz B. Increased survival utilizing delayed gamma knife radiosurgery for recurrent high grade glioma: a feasibility study. World Neurosurg. 2014 Jun 12.

12. Bodo Lippitz: Stereotactic Radiosurgery as Salvage Treatment for malignant glioma: A Review Submitted 2014

13. Bodo Lippitz: Gamma Knife Radiosurgery in the treatment of Pituitary Adenoma: Submitted 2014

14. Bodo Lippitz, Erik Jensen, Magnus Backheden: 10- year Follow-up after Radiosurgery of Meningioma, J Neurosurg submitted 2014

15. Bodo Lippitz, Tobias Nelder, Heather Martin,: A Potential Algorithm for the Prediction of Adverse Radiation Effects in the Radiosurgical Treatment of Brain Metastases J Neurosurg submitted 2014

16. Bodo Lippitz, Ian Paddick, Magnus Backheden: Gamma Knife Radiosurgery in the Treatment of Cerebral Metastases: A Clinical Study, submitted 2014

17. Bodo Lippitz, Robert Harris: The Cytokine Pattern in Cancer Patients: The Prognostic Significance of Interleukin 6:  submitted

18. Bodo Lippitz: 10- year Follow-up after Radiosurgery of Pilocytic Astrocytoma, in preparation 2014

19. Bodo Lippitz, Mikäl Söderman M., Elisabeth Ronne-Engström, Per Enblad, Sandro Rossitti, Staffan Holmin: Gamma Knife Radiosurgery of Cerebral AVM: A Long-term Analysis, in preparation

Prof. Dr. med. Florian Würschmidt

Gedruckte Veröffentlichungen 

Baumann M, Würschmidt F, Twardy, A., & Beck-Bornholdt, H. P. (1994). Impact of tumor stroma on expression of the tumor bed effect in R1H rat rhabdomyosarcoma. Radiation Research, 140(3), 432–436. Beck-Bornholdt, H. P., Baumann M, Dubben, H. H., Würschmidt F, & Harvey, M. F. (1991a). The hazard of short overall treatment times in radiotherapy. Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology, 20(1), 66–68. Beck-Bornholdt, H. P., Omniczynski, M., Theis, E., Vogler, H., & Würschmidt F. (1991b). Influence of treatment time on the response of rat rhabdomyosarcoma R1H to fractionated irradiation. Acta Oncologica (Stockholm, Sweden), 30(1), 57–63. Blohmer, J.-U., Paepke, S., Sehouli, J., Boehmer, D., Kolben, M., Würschmidt, F., et al. (2011). Randomized Phase III Trial of Sequential Adjuvant Chemoradiotherapy With or Without Erythropoietin Alfa in Patients With High-Risk Cervical Cancer: Results of the NOGGO-AGO Intergroup Study. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Dellas, K., Höhler, T., Reese, T., Würschmidt, F., Engel, E., Rödel, C., et al. (2013). Phase II trial of preoperative radiochemotherapy with concurrent bevacizumab, capecitabine and oxaliplatin in patients with locally advanced rectal cancer. Radiation Oncology (London, England), 8(1), 90 Greulich-Bode, K. M., Zimmermann, F., Müller, W. U., Pakisch, B., Molls M, & Würschmidt F. (2012). Clinical, Molecular- and Cytogenetic Analysis of a Case of Severe Radio- Sensitivity. Current Genomics, 13(6), 426–432. Gündel, H., Lordick, F., Brandl, T., Würschmidt, F., Schüssler, J., Leps, B., et al. (2003). [Interdisciplinary psychoeducational intervention by oncologists proved helpful for cancer patients]. Zeitschrift Für Psychosomatische Medizin Und Psychotherapie, 49(3), 246–261. Kretschmer, M., Sabatino, M., Blechschmidt, A., Heyden, S., Grünberg, B., & Würschmidt, F. (2013). The impact of flattening filter-free beam technology on 3D conformal RT. Radiation Oncology, (8). Kretzler, A., Molls, M., Gradinger, R., Lukas, P., Steinau, H.-U., & Würschmidt, F. (2004). Intraoperative radiotherapy of soft tissue sarcoma of the extremity. Strahlenther Onkol, 180(6), 365–370. Lordick, F., Brandl, T., & Würschmidt F. (2003). [Interdisciplinary psychoeducatio… [Z Psychosom Med Psychother. 2003] Lordick, F., Gündel, H., Schilling, von, C., Würschmidt, F., Leps, B., Sendler, A., et al. (2002). [Structured patient education in oncology. A prospective study for implementing and effectiveness of interdisciplinary psycho-educational group intervention at a German university clinic]. Medizinische Klinik (Munich, Germany : 1983), 97(8), 449–454. Milewsky, F., Fassbender, T., Würschmidt F, & Beck-Bornholdt, H. P. (1990). A simple experimental technique for interstitial iridium-192 high dose-rate afterloading. Strahlenther Onkol, 166(9), 588–590. Petersen, S., Gaul, H., Caselitz, J., & Schwenk, W. (2012). Actinomyces infection mimicking tumor-progression in rectal cancer under neoadjuvant therapy. Acta Oncologica. Sabatino, M., Kretschmer, M., Zink, K., & Wuerschmidt, F. (2012). The impact of direct aperture optimization on plan quality and efficiency in complex head and neck IMRT. Radiation Oncology (London, England), 7(1), 7. Sommer, H., Weidner, N., Würschmidt F, & Engel, J. (2002). [Radiotherapy for endometrial cancer]. Zentralblatt Für Gynäkologie, 124(1), 51–57. Stadler, P., Becker, A., Feldmann, H. J., Hänsgen, G., Dunst, J., Würschmidt F, & Molls M. (1999). Influence of the hypoxic subvolume on the survival of patients with head and neck cancer. International Journal of Radiation Oncology, Biology, Physics, 44(4), 749–754. Willers, H., Würschmidt F, Bünemann, H., & Heilmann, H. P. (1998). High-dose radiation therapy alone for inoperable non-small cell lung cancer–experience with prolonged overall treatment times. Acta Oncologica (Stockholm, Sweden), 37(1), 101–105.

Würschmidt F, & Baumann M. (1995). [Successful use of adjuvant immunotherapy in resected colorectal tumors]. Strahlenther Onkol, 171(3), 175–176. Würschmidt F, & Beck-Bornholdt, H. P. (1995). Combined modality treatment of the rhabdomyosarcoma R1H of the rat: tumor and normal tissue response after cisplatin and conventional or accelerated irradiation treatment. International Journal of Radiation Oncology, Biology, Physics, 32(2), 391–394. Würschmidt F, & Heilmann, H. P. (1997). Continuous hyperfractionated accelerated therapy in non-small-cell lung cancer. Lancet, 350(9081), 888. Würschmidt F, Bardenheuer, M. J., Müller, W. U., & Molls M. (2000a). Chromosomal aberrations induced in mice bone marrow by treating with cisplatin and irradiation. Strahlenther Onkol, 176(7), 319–323. Würschmidt F, Beck-Bornholdt, H. P., & Vogler, H. (1990). Radiobiology of the rhabdomyosarcoma R1H of the rat: influence of the size of irradiation field on tumor response, tumor bed effect, and neovascularization kinetics. International Journal of Radiation Oncology, Biology, Physics, 18(4), 879–882. Würschmidt F, Beck-Bornholdt, H. P., Vogler, H., & Jung, H. (1991). Radiotherapy of the rhabdomyosarcoma R1H of the rat: split-course versus continuous fractionation. Strahlenther Onkol, 167(1), 26–30. Würschmidt F, Becker, S., Maurer, T., Omniczynski, M., Schelp, R., Vogler, H., & Beck-Bornholdt, H. P. (1992a). Radiotherapy of the rhabdomyosarcoma R1H of the rat: recovery from radiation injury in tumour and skin. Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology, 23(2), 105–110. Würschmidt F, Bünemann, H., & Heilmann, H. P. (1992b). Treatment of non-small-cell lung cancer with cisplatin and radiotherapy. The New England Journal of Medicine, 327(6), 432; author reply 433. Würschmidt F, Bünemann, H., & Heilmann, H. P. (1995a). Prognostic factors in high-grade malignant glioma. A multivariate analysis of 76 cases with postoperative radiotherapy. Strahlenther Onkol, 171(6), 315–321. Würschmidt F, Bünemann, H., & Heilmann, H. P. (1995b). Small cell lung cancer with and without superior vena cava syndrome: a multivariate analysis of prognostic factors in 408 cases. International Journal of Radiation Oncology, Biology, Physics, 33(1), 77–82. Würschmidt F, Bünemann, H., Bünemann, C., Beck-Bornholdt, H. P., & Heilmann, H. P. (1994a). [The radiotherapy of inoperable non-small-cell bronchial carcinoma. A retrospective analysis of 427 cases]. Strahlenther Onkol, 170(5), 302–304. Würschmidt F, Bünemann, H., Bünemann, C., Beck-Bornholdt, H. P., & Heilmann, H. P. (1994b). Inoperable non-small cell lung cancer: a retrospective analysis of 427 patients treated with high-dose radiotherapy. International Journal of Radiation Oncology, Biology, Physics, 28(3), 583–588. Würschmidt F, Bünemann, H., Ehnert, M., & Heilmann, H. P. (1997). Is the time interval between surgery and radiotherapy important in operable nonsmall cell lung cancer? A retrospective analysis of 340 cases. International Journal of Radiation Oncology, Biology, Physics, 39(3), 553–559. Würschmidt F, Fassbender, T., & Beck-Bornholdt, H. P. (2000b). Combined fractionated external beam radiotherapy and low-dose-rate iodine-125 seeds in an experimental tumor system. Strahlenther Onkol, 176(11), 524–527. Würschmidt, F., Dahle, J., Petersen, C., Wenzel, C., Kretschmer, M., & Bastian, C. (2008). Reirradiation of recurrent breast cancer with and without concurrent chemotherapy. Radiation Oncology (London, England), 3, 28. Würschmidt, F., Stoltenberg, S., Kretschmer, M., & Petersen, C. (2014). Incidental dose to coronary arteries is higher in prone than in supine whole breast irradiation : A dosimetric comparison in adjuvant radiotherapy of early stage breast cancer. Strahlenther Onkol, 190(6), 563–568.